Table 3.
Association between genetically influenced classical cardiovascular risk factors and atherogenic cardiovascular disease at different ages
| CAD | CAD (case < 50 years) | CAD (case 50–60 years) | CAD (case 60–70 years) | CAD (case > 70 years) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Body mass index | 1.10 | 1.08, 1.12 | 1.22 | 1.17, 1.28 | 1.14 | 1.11, 1.16 | 1.06 | 1.03, 1.08 | 1.02 | 0.97, 1.08 |
| Blood pressure | 1.08 | 1.06, 1.10 | 1.12 | 1.06, 1.17 | 1.09 | 1.07, 1.12 | 1.07 | 1.04, 1.09 | 1.04 | 0.98, 1.10 |
| LDL cholesterol | 1.11 | 1.10, 1.13 | 1.16 | 1.06, 1.22 | 1.15 | 1.12, 1.18 | 1.09 | 1.06, 1.11 | 1.02 | 0.97, 1.08 |
| Triglycerides | 1.06 | 1.05, 1.08 | 1.11 | 1.06, 1.16 | 1.06 | 1.03, 1.08 | 1.06 | 1.04, 1.09 | 1.04 | 0.99, 1.10 |
Analyses adjusted for sex and the first 10 principal components. Results presented as the increased odds in atherogenic cardiovascular disease per standard deviation increase in genetically determined body mass index, blood pressure, LDL cholesterol, or triglycerides with corresponding 95% confidence interval
Abbreviations: CAD, coronary artery disease; CI, confidence interval; LDL, low-density lipoprotein; OR, odds ratio