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. 2022 Jun 10:ciac471. doi: 10.1093/cid/ciac471

Multisystem Inflammatory Syndrome in Children (MIS-C) During SARS-CoV-2 Delta and Omicron Variant Circulation— United States, July 2021 – January 2022

Allison D Miller 1,, Anna R Yousaf 2, Ethan Bornstein 3,4,5, Michael J Wu 6, Katherine Lindsey 7, Michael Melgar 8, Matthew E Oster 9,10, Laura D Zambrano 11, Angela P Campbell 12
PMCID: PMC9214171  PMID: 35684958

Abstract

We describe 2,116 multisystem inflammatory syndrome in children (MIS-C) cases reported to CDC during Delta and Omicron circulation from July 2021–January 2022. Half of MIS-C patients were aged 5-11 years, 52% received ICU-level care, and 1.1% died. Only 3.0% of eligible patients were fully vaccinated prior to MIS-C onset.

Keywords: multisystem inflammatory syndrome in children, COVID-19, child, epidemiology

Contributor Information

Allison D. Miller, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Anna R. Yousaf, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Ethan Bornstein, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA; Northwest Portland Area Indian Health Board, Portland, OR, USA.

Michael J. Wu, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Katherine Lindsey, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Michael Melgar, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Matthew E. Oster, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA; Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA.

Laura D. Zambrano, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Angela P. Campbell, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Supplementary Material

ciac471_Supplementary_Data

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

ciac471_Supplementary_Data

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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