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. 2022 Jun 10;11(12):1893. doi: 10.3390/cells11121893

Figure 2.

Figure 2

Effect of anti-Ly6G antibody on body weight and skeletal muscle mass in the orthotopic KPC model of cancer cachexia. (A) Changes in body weight (mean and standard deviation) of Sham mice (Control; n = 8) and KPC tumor-bearing groups treated with either isotype control (IgG2a; n = 5) or anti-Ly6G antibody (n = 5) throughout study duration. (B) Tibialis anterior (C) and gastrocnemius/plantaris and (D) epididymal fat pad mass from control mice and KPC mice treated with isotype control or anti-Ly6G antibody at experimental endpoint. Open bars = control group; grey bars = tumor bearing. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significant (p > 0.05).