Figure 3.

Wound healing kinetics in PBS, dermal fibroblast (DFb) derived exosomes, and adipose stem cell (ASC) derived exosomes treated wounds. (A) Scheme illustrating the experimental procedure and treatment in db/db mice; (B) representative macroscopic images and quantification of raw surface, re-epithelialization, and contraction. (n = 8/group); (C) time-course changes of raw surface revealed significant differences were found on day 10, 14 and 17 (* compare with DFb or PBS, p < 0.05; # compare with DFb or PBS, p < 0.01); (D) enhanced wound contraction was found in ASC-Exo treated wounds on day 10, 14 and 17 (* p < 0.05; ** p < 0.01); (E) re-epithelialization was enhanced in ASC-Exo treated wounds when compared with DFb-Exo and PBS group on day 14 and 17 (** p < 0.01). Error bars are mean ± SE. Data were analyzed using independent unpaired two-tailed Student’s t-tests.