Table 2.
Anti-inflammatory, synergistic interaction, therapeutic index and cytotoxicity parameters of ginger and turmeric extracts in inhibiting LPS-induced TNF production in THP-1 cells (n > 3 of experiments).
| Extracts and Combinations |
Cell Viability LC50 (µg/mL) |
IC50 (µg/mL) Mean ± STD |
CI Value at IC50 | Therapeutic Index |
|---|---|---|---|---|
| G | 123.8 ± 9.10 | 28.04 ± 3.99 | N/A | N/A |
| T | 47.24 ± 7.84 | 8.54 ± 1.43 | N/A | 5.53 |
| G-T 1:9 | 40.94 ± 11.08 ∆ | 7.40 ± 1.32 ∆ | 1.52 | 5.53 |
| G-T 2:8 | 41.16 ± 10.90 ∆ | 5.99 ± 0.70 ∆ | 0.60 | 6.87 |
| G-T 3:7 | 45.30 ± 6.74 ∆ | 5.72 ± 0.57 ∆ | 0.11 | 7.92 |
| G-T 4:6 | 52.03 ± 8.97 ∆ | 8.43 ± 1.25 ∆ | 0.71 | 6.17 |
| G-T 5:5 | 53.16 ± 7.79 ∆ | 8.37 ± 1.44 ∆ | 0.64 | 6.35 |
| G-T 6:4 | 51.26 ± 7.62 ∆ | 4.79 ± 1.08 ∆ | 0.33 | 10.70 |
| G-T 7:3 | 52.61 ± 5.41 ∆ | 13.24 ± 3.11 ∆ | 0.80 | 3.97 |
| G-T 5:2 | 73.61 ± 8.05 ∆,& | 8.32 ± 1.85 ∆ | 0.49 | 8.85 |
| G-T 8:2 | 56.35 ± 6.25 ∆ | 15.58 ± 2.93 ∆ | 0.81 | 3.62 |
| G-T 9:1 | 118.90 ± 6.52 & | N/A | N/A | N/A |
∆p < 0.05 compared with G; & p < 0.05 compared with T as analysed by one-way ANNOVA test. N/A: not available.