Table 2.
Ex vivo pharmacokinetic parameters of 89Zr-Exo following i.v. administration in various organs of ICR mice.
| Organ | Cmax [%ID] | Tmax [d] | AUC0–t [%ID × d] |
|---|---|---|---|
| Liver | 58.22 | 0.08 | 367.59 |
| Spleen | 6.35 | 0.01 | 21.13 |
| Brain | 0.04 | 0.04 | 0.20 |
| Small intestine | 3.41 | 0.08 | 2.23 |
| Large intestine | 6.49 | 0.25 | 4.19 |
| Stomach | 0.49 | 0.25 | 0.96 |
| Kidney | 1.05 | 0.25 | 4.63 |
| Urine * | 5.22 | 0.01 | 7.65 |
| Lung | 0.79 | 0.01 | 1.17 |
| Heart | 0.07 | 0.01 | 0.27 |
| Thyroid | 0.02 | 0.08 | 0.15 |
| Testis | 0.04 | 7.00 | 0.20 |
| Ovary | 0.06 | 0.04 | 0.19 |
| Muscle * | 0.15 | 7.00 | 0.86 |
| Femur * | 2.20 | 0.01 | 9.59 |
| Blood * | 0.23 | 0.01 | 0.53 |
* Unit (concentration) = %ID/g.