Table 3.
In vivo pharmacokinetic parameters of 89Zr-Exo following i.v. administration in various organs of SD rats.
| Organ | Cmax [%ID] (n) | Tmax [d] (n) | AUC0-t [%ID × d] (n) |
|---|---|---|---|
| Liver | 63.58 ± 12.67 (6) | 1.56 ± 2.70 (6) | 332.14 ± 50.00 (6) |
| Spleen | 2.00 ± 0.65 (6) | 3.02 ± 3.21 (6) | 10.82 ± 3.15 (6) |
| Brain | 0.00 ± 0.01 (6) | 0.25 ± NA (1) | 0.00 ± 0.00 (6) |
| Intestine | 3.71 ± 1.84 (6) | 0.61 ± 0.76 (6) | 9.58 ± 4.67 (6) |
| Stomach | 0.18 ± 0.12 (6) | 1.50 ± 2.71 (6) | 0.48 ± 0.28 (6) |
| Kidney | 0.34 ± 0.17 (6) | 0.60 ± 0.77 (6) | 1.03 ± 0.84 (6) |
| UB | 2.95 ± 2.91 (6) | 0.06 ± 0.03 (6) | 0.60 ± 0.32 (6) |
| Lung | 0.49 ± 0.16 (6) | 0.22 ± 0.39 (6) | 1.58 ± 0.61 (6) |
| Heart | 0.42 ± 0.13 (6) | 0.22 ± 0.40 (6) | 1.55 ± 0.53 (6) |
Values are the mean ± SD.