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. 2022 May 30;14(6):1172. doi: 10.3390/pharmaceutics14061172

Figure 5.

Figure 5

The excessive activation of NLRP3, IL-18, and IL-1β inflammasome in spontaneous miscarriage compared to normal pregnancy. Human primary endometrial stromal cells were transfected with miR-138-5P (25 nM) and si-GPR124 (50 nM) for 48 h. The endometrial stromal cell medium was collected at 48 h after transfection to assess IL-1β, IL-18, and NLRP3 levels. (A) The expressions of GPR124 and NLRP3 mRNA regulated by miR-138-5p in endometrial stromal cells. (B) The expressions of IL-18 and IL-1β mRNA regulated by miR-138-5p in endometrial stromal cells. (C) The expressions of GPR124 and NLRP3 mRNA regulated by si-GPR124 in endometrial stromal cells. (D) The expressions of IL-18 and IL-1β mRNA regulated by si-GPR124 in endometrial stromal cells. miRNA negative control (miR-NC). siRNA control (si-Ctrl). (* p < 0.05, versus control).