KEY RESOURCES TABLE

REAGENT OR RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-γCaMKII (ab01)	This paper	N/A
Rabbit anti-γCaMKII (ab02)	This paper	N/A
Mouse anti-PV	Swant	Cat#235; RRID: AB_10000343
Rabbit anti-PV	Abcam	Cat#ab11427; RRID: AB_298032
Rabbit anti-pGluR1 (S831)	Millipore	Cat#AB5847; RRID: AB_11211981
Mouse anti-GluRI	Millipore	Cat#MAB2263; RRID: AB_11212678
Mouse anti-NeuN	Abcam	Cat#ab104224; RRID: AB_10711040
Mouse anti-GAD67	Millipore	Cat#MAB5406; RRID: AB_2278725
Mouse anti-αCaMKII	Thermo Fisher Scientific	Cat#MA1-048; RRID: AB_325403
Mouse anti-βCaMKII	Thermo Fisher Scientific	Cat#139800; RRID: AB_2533045
Rabbit anti-δCaMKII	Invitrogen	Cat#PA5-22168; RRID: AB_11153337
Rabbit anti-NR2A	Abcam	Cat#ab133265; RRID: AB_11158532
Rabbit anti-β-actin	Cell Signaling Technology	Cat#4970; RRID: AB_2223172
Bacterial and virus strains
AAV2/9-hSyn-DIO-mCherry-P2A-HA-HsγCaMKII-WT/K43R	Taitool Bioscience	AAV2/9-WY2498 AAV2/9-WY2499
AAV2/9-hEF1 α-DIO-mCherry	Taitool Bioscience	AAV2/9-S0197
AAV2/9-EF1 α-pDIO-DSE-mCherry-PSE-γCaMKII shRNA	Sunbio Medical Biotechnology	pAAVE3082
Chemicals, peptides, and recombinant proteins
DAPI Fluoromount-G	Yeasen Biotechnology	Cat#36308ES20
Cresyl violet	Sigma-Aldrich	Cat#C5042
Protease inhibitor cocktail	Roche	Cat#04693132001
Picrotoxin	Tocris	Cat#1128
D-AP5	Abcam	Cat#ab120003
TTX	Absin	Cat#abs44200985a
NBQX	Abcam	Cat#ab120046
12-myristate 13-acetate (PMA)	MedChemExpress	Cat#HY-18739
Critical commercial assays
BCA protein assay	Thermo Fisher Scientific	Cat#23227
Enhanced chemiluminescence (ECL) detection system	Yeasen Biotechnology	Cat#36222
RNAscope Multiplex Fluorescent v2	Advanced Cell Diagnostics	Cat#323110
RNAscope H2O2 and Protease Reagents	Advanced Cell Diagnostics	Cat#322381
Lipofectamine 3000 Transfection Reagent	Thermo Fisher Scientific	Cat# L3000008
Experimental models: cell lines
HEK293	ATCC	CRL-321
Experimental models: organisms/strains
Mouse: C57BL/6J	The Jackson Laboratory	JAX: 000664; RRID: IMSR_JAX:000664
Mouse: γCaMKII-KO	Lab of Eric N. Olson	N/A
Mouse: γCaMKIILoxP/LoxP	Lab of Eric N. Olson	N/A
Mouse: PV-Cre	The Jackson Laboratory	JAX: 008069; RRID: IMSR_JAX:008069
Mouse: GAD2-IRES-Cre	The Jackson Laboratory	JAX: 010802; RRID: IMSR_JAX:010802
Mouse: T29-1. CaMKIIα-Cre	The Jackson Laboratory	JAX: 005359; RRID: IMSR_JAX:005359
Mouse: Ai14LoxP/LoxP	The Jackson Laboratory	JAX: 007908; RRID: IMSR_JAX:007908
Mouse: Ai32LoxP/LoxP	The Jackson Laboratory	JAX: 012569; RRID: IMSR_JAX:012569
Oligonucleotides
shRNA targeting sequence: γCaMKII	This paper	N/A
5′-GCAGCTTGCATCGCCTATATC-3′
Recombinant DNA
Plasmid: GluR1 WT	This paper	N/A
Plasmid: GluR1 S831A	This paper	N/A
Software and algorithms
ANY-maze automated tracking system	Stoelting	https://www.stoeltingco.com/any-maze-video-tracking-software-1224.html
EthoVision tracking software	Noldus	https://www.noldus.com/ethovision-xt
ImageJ	NIH	https://imagej.nih.gov/ij/
Prism	Graphpad	https://www.graphpad-prism.cn
Clampfit	Molecular Devices	v.10.4
NeuroExplorer 5	Mizuseki et al., 2009	https://www.neuroexplorer.com/
MATLAB	MathWorks	https://www.mathworks.com/products/matlab/
Statistical Toolbox	MathWorks	https://www.mathworks.com/products/statistics.html
Offline Sorter	Plexon	https://plexon.com/products/offline-sorter/
Klusters	Mizuseki et al., 2009	http://neurosuite.sourceforge.net/
Kilosort	Github	https://github.com/cortex-lab/KiloSort
FMAToolbox	M.Z., College de France	http://fmatoolbox.sourceforge.net
Buzcode	Github	https://github.com/buzsakilab/buzcode
Other
RNAscope probe: Mm-αCaMKII-C3	Advanced Cell Diagnostics	Cat#445231-C3
RNAscope probe: Mm-βCaMKII	Advanced Cell Diagnostics	Cat#453601
RNAscope probe: Mm-γCaMKII-C2	Advanced Cell Diagnostics	Cat#522071-C2
RNAscope probe: Mm-δCaMKII	Advanced Cell Diagnostics	Cat#508941