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. 2022 Jun 29;81:104132. doi: 10.1016/j.ebiom.2022.104132

Figure 5.

Figure 5

Genome-wide transcriptomic analysis in human airway organoids upon seasonal coronavirus infection. (A) Principal component analysis (PCA) of different organoid samples (U: Undifferentiated hAOs; D: Differentiated hAOs). (B) Top 40 significantly enriched pathways by gene ontology (GO) analysis of hAOs cultured at 37 °C. (C to E) Venn diagram of overlapped differentially expressed genes (C) in differentiated and undifferentiated airway organoids cultured at 33 °C and 37 °C, (D) 229E virus infection in undifferentiated hAOs or differentiated hAOs cultured at 33 °C and 37 °C, (E) OC43 virus infection in undifferentiated hAOs or differentiated hAOs cultured at 33 °C and 37 °C. (F to I) Differential gene expression analysis by coronavirus infections in undifferentiated hAOs, (F) 229E infection at 33 °C, (G) 229E infection at 37 °C, (H) OC43 infection at 33 °C, (I) OC43 infection at 37 °C.