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. 2022 Jun 29;27(3):295–305. doi: 10.1007/s12257-021-0355-z

Recent Progress in Microalgal Squalene Production and Its Cosmetic Application

Çağla Yarkent 1, Suphi S Oncel 1,✉
PMCID: PMC9244377  PMID: 35789811

Abstract

Squalene, [oxidized form squalane] is a terpenoid with biological activity that produced by animals and plants. In the human body, a significant excretion named as sebum includes squalene in 12 percent. This bioactive compound shows anti-inflammatory, detoxifying, moisturizing and antioxidant effects on the human body. In addition to having these properties, it is known that squalene production decreases as less sebum is produced with age. Because of that, the need for supplementation of squalene through products has arisen. As a result, squalene production has been drawn attention due to its many application possibilities by cosmetic, cosmeceutical and pharmaceutical fields. At this point, approximately 3,000 of sharks, the major and the most popular source of squalene must be killed to obtain 1 ton of squalene. These animals are on the verge of extinction. This situation has caused to focus on finding microalgae strains, which are sustainable producers of squalene as alternative to sharks. This review paper summarizes the recent progresses in the topic of squalene. For this purpose, it contains information on squalene producers, microalgal squalene production and cosmetic evaluation of squalene.

Keywords: squalene, microalgae, microalgal process, bioactive compound, cosmetics

Acknowledgements

This study was funded by TUBITAK (The Scientific and Technological Research Council of Turkey), grant number 221M029 as a part of a PhD thesis in Ege University Bioengineering Department, Microalgal Bioprocess Research Group.

Ethical Statements

The authors declare no conflict of interest.

Neither ethical approval nor informed consent was required for this study.

Footnotes

Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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