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. Author manuscript; available in PMC: 2022 Jun 30.
Published in final edited form as: Pain. 2020 Oct;161(10):2330–2343. doi: 10.1097/j.pain.0000000000001926

Table 1.

Differential nociceptive behavior and designated behavior phenotype in response to cell line culture supernatant.

Cell type Cell line Source %Δ in gnaw-time Behavior phenotype
 Skin keratinocytes (immortalized) HaCaT AddexBio 6.5 ± 14.9 Nonnociceptive
 Normal oral keratinocytes (primary) NOK Lifeline Cell Tech 2.1 ± 10.4 Nonnociceptive
 Dysplastic oral keratinocytes DOK Sigma 3.3 ± 7.7 Nonnociceptive
 Melanoma SkMel-28 ATCC 12.9 ± 8.1 Nonnociceptive
 Oral squamous cell carcinoma HSC-3 JCRB 80.2 ± 13.9 Nociceptive
 Oral squamous cell carcinoma SCC-4 ATCC 70.2 ± 13.6 Nociceptive
 Oral squamous cell carcinoma SCC-9 ATCC 50.7 ± 6.7 Nociceptive
 Pancreatic carcinoma PANC-1 ATCC 55.0 ± 6.2 Nociceptive

NOK, normal primary oral keratinocyte; DOK, oral dysplastic keratinocyte; SCC, squamous cell carcinoma.