Table 2.
Differentially expressed genes for nociception also identified in a proteomic literature review.
| Gene symbol | Protein name | Probe ID 1 | logFC 1 | Probe ID 2 | logFC 2 | Articles (PMID) |
|---|---|---|---|---|---|---|
| ACTN1 | Alpha-actinin-1 | 211160_x_at | 0.78 | — | — | 24495306; 26850699 |
| ADAM17 | ADAM17 | 213532_at | 1.24 | — | — | 23090842 |
| BASP1 | Brain acid soluble protein 1 | 202391_at | 5.49 | — | — | 26850699 |
| CAPRIN1 | Caprin-1 | 200723_s_at | 0.99 | — | — | 24495306 |
| CBX3 | Chromobox protein homolog 3 | 201091_s_at | 1.44 | — | — | 24211406 |
| CNDP2 | Camosine dipeptidase 2 | 1562460_at | −1.05 | — | — | 26850699 |
| EGFR | Epidermal growth factor receptor | 1565483_at | −1.67 | — | — | 22902387; 23090842 |
| EXT2 | Exostosin-2 | 202012_s_at | 0.88 | — | — | 23090842 |
| F2RL1 | Proteinase-activated receptor 2 | 213506_at | 3.49 | — | — | 23090842 |
| FSCN1 | Fascin | 201564_s_at | 2.37 | — | — | 24495306 |
| GSN | Isoform 1 of gelsolin | 214040_s_at | −4.48 | 200696_s_at | −3.25 | 22905270 |
| ITGA3 | Integrin α3 | 201474_s_at | 3.05 | — | — | 23090842 |
| ITGB1 | Fibronectin receptor (integrin β1) | 1553678_a_at | 2.48 | 211945_s_at | 1.37 | 16215274 |
| ITGB4 | Integrin β4 | 204990_s_at | 3.21 | — | — | 23090842 |
| KRT19 | Cytokeratin 19 | 201650_at | 6.99 | — | — | 23463621 |
| LAMB1 | Laminin, beta 1 | 211651_s_at | 2.19 | 201505_at | 1.79 | 25484078 |
| LIF | Leukemia inhibitory factor | 205266_at | −1.91 | — | — | 25484078 |
| NSUN2 | tRNA (cytosine(34)-C(5))-methyltransferase | 223076_s_at | 1.25 | — | — | 24211406 |
| NUCB2 | Nucleobindin-2 | 203675_at | 2.23 | — | — | 24495306 |
| PCDH1 | Protocadherin-1 | 203918_at | −1.77 | — | — | 24211406 |
| PLAU | Urokinase-type plasminogen activator | 211668_s_at | 4.74 | 205479_s_at | 3.80 | 26850699 |
| PLS3 | Plastin-3 | 201215_at | 1.04 | — | — | 26850699 |
| PSMA3 | Proteasome subunit alpha type-3 | 201532_at | 0.95 | — | — | 23090842 |
| PSMC6 | 26S protease regulatory subunit S10B | 201699_at | 1.36 | — | — | 23090842; 24495306 |
| PYGB | Glycogen phosphorylase | 201481_s_at | −2.29 | — | — | 26850699 |
| SERPINB1 | Plasminogen activator inhibitor 1 | 213572_s_at | 1.74 | 228726_at | 2.20 | 26850699 |
| TIMP2 | Metalloproteinase inhibitor 2 | 203167_at | −1.75 | — | — | 25484078; 26850699 |
| TMTC3 | Transmembrane and TPR repeat-containing protein 3 | 226600_at | 2.36 | 226604_at | 2.81 | 23090842 |
| TUBB | Tubulin beta chain | 212320_at | 0.87 | — | — | 23090842 |
| VCL | Vinculin | 200931_s_at | 1.51 | — | — | 16215274 |
Genes identified in the proteomic literature review were also differentially expressed in the nociceptive cell line analysis and corresponding Affymetrix U133 Plus 2.0 probe IDs. The log fold-change (FC) values for each significant gene-probe (P < 0.05 is estimated as significant using the moderated ttest employed in limma) are listed. The PMID is the PubMed publication identifier.
EGFR, epidermal growth factor receptor.