Correction for Chiner-Oms et al., Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection

Microbiology Correction for “Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection,” by Álvaro Chiner-Oms, Mariana G. López, Miguel Moreno-Molina, Victoria Furió, and Inaki Comas, which published April 22, 2022; 10.1073/pnas.2113600119 (Proc. Natl. Acad. Sci. U.S.A. 119, e2113600119).

The authors note that Fig. 1 appeared incorrectly. The corrected figure and its legend appear below. The online version has been corrected.

Fig. 1.

Gene-by-Gene calculation of pN/pS over phylogenetic time. (A) Bar plot showing the number of genes currently displaying a pN/pS > 1 and a pN/pS < 1. (B) From the alignment, we inferred the current pN/pS; however, when mapping different mutations onto the phylogeny, we inferred how the pN and pS rates changed over time. (C) Five categories grouping studied genes according to their trajectories.

The authors note that on page 9, right column, second full paragraph, line 1, “Mean pN/pS across time for each gene and for the complete genome were calculated as $mean pN/pS = \frac{\sum _{t=4}^n x_t}{n - 4}$ , with x being the cumulative pN/pS value at each of the sampled t points.” should instead appear as “Mean pN/pS across time for each gene and for the complete genome were calculated as $mean pN/pS =\hspace{0.17em}\frac{\sum _{t=4}^n x_t}{n - 3}$, with x being the cumulative pN/pS value at each of the sampled t points.” The online version has been corrected.

The authors note that on page 10, left column, third full paragraph, line 9, “Parameters were estimated using Markov chain Monte Carlo (MCMC) Bayesian inference with 1 × 107-step-long chains with the exception of the larger datasets (L2, L3,L4.1.2, L4.3.4, L4.10), for which longer chains were run (1 × 108) and the tree topology was fixed.” should instead appear as “Parameters were estimated using Markov chain Monte Carlo (MCMC) Bayesian inference with 1 × 10⁷-step-long chains with the exception of the larger datasets (L2, L3,L4.1.2, L4.3.4, L4.10), for which longer chains were run (1 × 10⁸) and the tree topology was fixed.” The online version has been corrected.

The authors note that the Acknowledgments section should be corrected. The new Acknowledgments section should read: “This project received funding from the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program Grant 101001038 (TB-RECONNECT). In addition, this work was funded by Ministerio de Ciencia (Spanish Government) Project PID2019-104477RB-I00, Generalitat Valenciana Project AICO/2018/113 and Caixa Research Grant HR21-00415 (TB-TARGET). This research work was also funded by the European Commission–NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform (PTI Salud Global).” The online version has been corrected.