Table 2.
Factors correlated with nodal metastasis in clinically node negative (cN0) patients.
| Parameters |
Total N = 750 (%) |
LN (+) N = 135 (%) |
LN (−) N = 615 (%) |
p value |
Multivariate analysis |
|||
|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p value | ||||||
| Age (years) | ≤50 >50 |
302 (40.3) 448 (59.7) |
59 (43.7) 76 (56.3) |
243 (39.5) 372 (60.5) |
0.369 | |||
| Quadrant | Upper outer Upper inner Lower inner Lower outer Central |
267 (35.6) 190 (25.3) 71 (9.5) 146 (19.5) 76 (10.1) |
54 (40.0) 24 (17.8) 9 (6.7) 32 (23.7) 16 (11.9) |
213 (34.6) 166 (27.0) 62 (10.1) 114 (18.5) 60 (9.8) |
0.093 | – | ||
| Quadrant | Strictly UOQ Others |
247 (32.9) 503 (67.1) |
52 (38.5) 83 (61.5) |
195 (31.7) 420 (68.3) |
0.127 | – | ||
| Tumor foci | Unifocal Multifocal |
713 (95.1) 37 (4.9) |
126 (93.3) 9 (6.7) |
587 (95.4) 28 (4.6) |
0.304 | – | ||
| Injection interval | Same day Overnight |
594 (79.2) 156 (20.8) |
110 (81.5) 25 (18.5) |
484 (78.7) 131 (21.3) |
0.471 | – | ||
| Breast surgical method | BCS Mastectomy |
391 (52.1) 359 (47.9) |
58 (43.0) 77 (57.0) |
333 (54.1) 282 (45.9) |
0.019 | 1 1.28 |
0.85–1.93 | 0.234 |
| IHC markers | ER (+) ER (−) |
596 (79.5) 154 (20.5) |
109 (80.7) 26 (19.3) |
487 (79.2) 128 (20.8) |
0.686 | – | ||
| PR (+) PR (−) |
547 (72.9) 203 (27.1) |
103 (76.3) 32 (23.7) |
444 (72.2) 171 (27.8) |
0.331 | – | |||
| HER2 (+) HER2(−) |
120 (16.0) 630 (84.0) |
17 (12.6) 118 (87.4) |
103 (16.7) 512 (83.3) |
0.233 | – | |||
| Subtype by IHC | Luminal A Luminal B HER2(+)HR (+) HER2(+)HR (−) Triple Negative |
183 (24.4) 365 (48.7) 58 (7.7) 87 (11.6) 57 (7.6) |
35 (25.9) 65 (48.1) 12 (8.9) 18 (13.3) 5 (3.7) |
148 (24.1) 300 (48.8) 46 (7.5) 69 (11.2) 52 (8.5) |
0.384 | – | ||
| T stage | T1mi/T1a T1b T1c T2 T3 |
89 (11.9) 63 (8.4) 277 (36.9) 311 (41.5) 10 (1.3) |
3 (2.2) 1 (0.7) 43 (31.9) 88 (65.2) 0 |
86 (14.0) 62 (10.1) 234 (38.0) 223 (36.3) 10 (1.6) |
<0.0001 | 1 0.48 4.27 7.10 0.43 |
0.08–2.95 1.51–12.09 2.55–19.78 0.02–10.68 |
0.424 0.006 <0.001 0.606 |
| Lymphovascular invasion | No Yes Unknown |
613 (81.7) 119 (15.9) 18 (2.4) |
83 (61.5) 50 (37.0) 2 (1.5) |
530 (86.2) 69 (11.2) 16 (2.6) |
<0.0001 | 1 3.11 0.88 |
1.98–4.86 0.22–3.52 |
<0.0001 0.853 |
Abbreviation: BCS: breast conserving surgery.