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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Matter. 2022 Mar 21;5(6):1816–1838. doi: 10.1016/j.matt.2022.03.001

Figure 7.

Figure 7.

Liposomal hydrogels enable synchronized and sustained co-delivery of IgG antibody and IL-12 cytokine cargo in vivo, despite substantial size difference. (A) Liposomal hydrogel mesh size is able to significantly slow release of bulky IgG antibodies, while anionic liposomes regulate release of small IL-12 cytokines via electrostatic interactions. Representative IVIS images of (B) Alexa Fluor 594 labeled IgG and (C) Alexa Fluor 700 labeled IL-12 release over time. Quantified release curves of IgG and IL-12 following (D) local subcutaneous bolus injection or (E) subcutaneous injection of liposomal hydrogel. Sample size was n=3 for bolus and n=4 for hydrogel groups.