Table 2.
Predictors of graft survival deemed significant or unspecified by included studies.
| Predictor Category | Timepoint | Studies which Predictor was Significant | Predictor(s) Significant on AnalysisNo p-value provided, but deemed significant by studyANo p-value provided, nor deemed significant by studyB | Control/Reference Group | HR (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Recipient age | Overall | Nagai (2019)14 Dimou (2016)15 Agbim (2019)18 |
60–64 65–69 70+ Age at transplantA: ≥65 Age at transplant: overall |
Vs. <50 Vs. <50 Vs. <50 <50 NR |
1.8 (1.2–2.71) 2.11 (1.39–3.21) 2.65 (1.5–4.69) 1.73 (1.38–2.18) 1.03 (1.02–1.04) |
0.004 <0.001 0.02 NR <0.001 |
| 1 year | Nagai (2019)14 | 50–59 60–64 65–69 70+ |
Vs. <50 Vs. <50 Vs. <50 Vs. <50 |
1.42 (1.05–1.92) 1.53 (1.12–2.08) 1.98 (1.45–2.71) 2.19 (1.49–3.22) |
0.02 0.007 <0.001 <0.001 |
|
| Recipient BMI | Overall | Dimou (2016)15 Agopian (2012)26 |
BMIA: 25–29 30–34 35–39 BMI: >35 |
Vs. <25 Vs. <25 Vs. <25 <35 |
0.7 (0.56–0.87) 0.74 (0.6–0.92) 0.79 (0.63–0.99) 2.1 (NR) |
NR NR NR 0.039 |
| 10 years | Satapathy (2020)27 | BMI: 25 to <30 ≥30 to <35 ≥35 to <40 ≥40 |
Vs. ≥18 to <25 Vs. ≥18 to <25 Vs. ≥18 to <25 Vs. ≥18 to <25 |
0.62 (0.48–0.79) 0.68 (0.54–0.87) 0.66 (0.51–0.86) 0.64 (0.46–0.89) |
<0.001 0.004 0.01 0.008 |
|
| Dialysis prior to LT | Overall | Agopian (2012)26 Zhang (2019)28 |
Dialysis prior to LT Dialysis prior to LT |
Vs. no dialysis Vs. no dialysis |
2.2 (NR) 1.4 (1.07–1.84) |
0.037 0.015 |
| Diabetes Mellitus | Overall | Dimou (2016)15 Agbim (2019)18 |
Diabetes mellitusA Diabetes mellitusA |
Vs. no DM Vs. no DM |
1.21 (1.06–1.39) 1.11 (0.98–1.25) |
NR <0.001 |
| Serum bilirubin | Overall | Agbim (2019)18 | TSB | NR | 1.01 (1.01–1.02) | <0.001 |
| Portal Vein Thrombosis | Overall | Agbim (2019)18 | Portal vein thrombosis | NR | 1.37 (1.15–1.63) | <0.001 |
| Ventilatory Support or ICU at LTX | Overall | Zhang (2019)28 | Ventilatory support or ICU at LT: Hospitalized not ICU Not hospitalized |
Vs. ICU Vs. ICUI |
0.72 (0.56–0.94) 0.57 (0.43–0.75) |
0.014 <0.0001 |
| Every 90d on wait listX | Overall | Zhang (2019)28 | Every 90d on waiting list | NS | 1.04 (1.01–1.07) | 0.011 |
| Recipient MELD | Overall | Dimou (2016)15 | MELDA: 30–39 ≥40 |
Vs. <20 Vs. <20 |
1.86 (1.53–2.23) 2.0 (1.49–2.69) |
NR NR |
| Type of Donor | Overall | Dimou (2016)15 | Type of Donor: Extended criteria donorB |
Vs. no ECD |
1.18 (1.03–1.36) |
NR |
| Allograft MacrosteatosisX | 1 year | Altshuler (2022)30 | Macrosteatosis ≥30% | Vs. <30% | 1.44 (1.01–2.06) | 0.05 |
X
Not an a priori determined variable- added in during data extraction.