ALS |
amyotrophic lateral sclerosis |
OS |
oxidative stress |
MNs |
motor neurons |
SOD1 |
superoxide dismutase 1 |
TDP-43 |
transgenic binding protein 43 |
FUS |
fused in sarcoma |
MATR 3 |
matrin 3 |
CHCHD10 |
coiled-coil-helix-coiled-coil-helix domain containing 10 |
TBK1 |
tank-binding kinase 1 |
TUBA4A |
tubulin, alpha 4A |
C21orf2 |
chromosome 21 open reading frame 2 |
C9orf72 |
chromosome 9 open reading frame 72 |
CCNF |
cyclin F |
OXPHOS |
oxidative phosphorylation |
ROS |
reactive oxygen species |
NADH |
nicotinamide adenine dinucleotide |
FADH2 |
reduced flavin adenine dinucleotide |
ETC |
electron transport chain |
IMM |
inner mitochondrial membrane |
MCU |
mitochondrial calcium uniporter |
OMM |
outer mitochondrial membrane |
IMS |
inter membrane space |
Grxs |
glutaredoxins |
DPR |
dipeptide repeat |
TIMMDC1 |
translocase of inner mitochondrial membrane domain containing 1 |
Fis1 |
mitochondrial fission protein 1 |
Mfn1 |
mitofusin 1 |
Drp1 |
dynamin-related protein 1 |
Opa1 |
optic atrophy 1 |
OPTN |
optineurin |
LIR |
LC3-interacting region |
SQSTM1 |
Sequestosome 1 |
H2S |
hydrogen sulfide |
CAT |
catalase |
PUFAs |
polyunsaturated fatty acids |
mtDNA |
mitochondrial DNA |
Nrf2 |
nuclear factor erythroid 2-related factor 2 |
ARE |
antioxidant response element |
VDACs |
voltage-dependent anion-selective channel proteins |
ER |
endoplasmic reticulum |
AMPA |
α-amino-5-methyl-3-hydroxyisoxazolone-4-propionic acid |
VAPB |
vesicle-associated membrane protein-associated proteins B and C |
PTPIP51 |
protein tyrosine phosphatase-interacting protein 51 |
NMDA |
N-methyl-D-aspartic acid receptor |
MANs |
mitochondria-associated endoplasmic reticulum membranes |
TRPM7 |
transient receptor potential cation channel subfamily M member 7 |
hIGF-1 |
human insulin-like growth factor 1 |
PPARγ |
peroxisome-promoting life-activating receptor γ |
TMP |
Tetramethylpyrazine nitric acid |
MitoQ |
Mitoquinolmesylate |
mPTP |
mitochondrial permeability transition pore |
TSPO |
translocator protein |
SHED-CM |
stem cells from human exfoliated deciduous teeth-conditioned medium |