Table 4. Frequencies of single nucleotide polymorphism (SNP) of HBB gene and association analysis with susceptibility to severe malaria (SM).
| HBB-SNP | NCBI dbSNP number | Phénotype (NCBI) | MAF | HWE | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SM | UM | CTR | Overall population | SM vs UM | UM vs CTR | SM vs CTR | |||||
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |||||||
| +526_C >T | rs7946748 | β-thalassemia | 0.06 | 0.03 | 0.06 | 0.05 | 0.06 | 0.048 | 0.41 (0.17–0.97) | 1 | |
| +519_T >G | rs7480526 | Benign | 0.34 | 0.40 | 0.33 | 0.36 | 0.14 | 0.14 | 1 | ||
| +461_C >G | rs10768683 | Benign | 0.09 | 0.06 | 0.09 | 0.08 | 0.26 | 0.14 | 0.75 | ||
| +446_G >A | rs33945777 | E6 familial, Fetal HQTL-1, Hb SS disease, H-B-A, MTH β type, α- β-thalassemia. | 0.008 | 0 | 0 | 0.002 | 0.19 | 1 | 0.50 | ||
| +436_G >T | rs35209591 | E6 familial | 0.39 | 0.41 | 0.42 | 0.41 | 0.61 | 0.93 | 0.56 | ||
| +200_T >C | rs111851677 | β-thalassemia | 0.02 | 0.03 | 0.02 | 0.02 | 0.79 | 1 | 1 | ||
| +20_A >T | rs334 | HbS | 0.03 | 0.07 | 0.03 | 0.05 | 0.03 | 0.38 (0.16-0.91) | 0.26 | 0.45 | |
| +19_G >A | rs33930165 | HbC | 0 | 0.01 | 0.03 | 0.01 | 0.26 | 0.17 | 0.008 | ||
| +9_C >T | rs713040 | Hemoglobin OKAYAMA | 0.11 | 0.07 | 0.12 | 0.10 | 0.10 | 0.03 | 0.51 (0.27-0.93) | 0.66 | |
| −79_A >G | rs34598529 | E6 familial, Fetal HQTL-1, Hb SS disease, H-B-A, MTH β type, α- β-thalassemia. | 0.004 | 0 | 0 | 0.001 | 0.44 | 1 | 1 | ||
| −133_G >A | rs72561473 | β-thalassemia | 0.012 | 0.019 | 0.010 | 0.014 | 0.737 | 0.486 | 1 | ||
| −138_C >T | rs33944208 | β-thalassemia, Hemoglobinopathy | 0 | 0 | 0.005 | 0.002 | 1 | 0.159 | 0.206 | ||