Table 1.

Summary of the anticancer activities of edible and medicinal fungi.

Name	Main Active Components	Cancer	Target/Mechanism	Ref.
Coriolus versicolor	Polysaccharide	ER-positive breast cancer and amelanotic melanoma cells	Induce RIPK1/RIPK3/MLKL-mediated necroptosis	[32]
Coriolus versicolor	Polysaccharide	Amelanotic melanoma cells	Trigger caspase-independent cell death pathway	[33]
Coriolus versicolor	Polysaccharide	Tumor cell lines	Induce cell cycle arrest and apoptosis	[34]
Ganoderma lucidum	Polysaccharide	Colorectal cancer	Activate MAPK/ERK signaling pathway, induce autophagosome accumulation and apoptosis	[35]
Ganoderma lucidum	Polysaccharide	Breast cancer	Combination with paclitaxel inhibits tumor metabolism through intestinal microbiota remodeling	[36]
Ganoderma lucidum	Polysaccharide	Lung cancer	Induce degradation of TGFβ and EGF receptors via proteasome and lysosome	[37]
Ganoderma lucidum	Triterpene	Prostate cancer	Regulate matrix metalloproteinases	[27]
Ganoderma lucidum	Triterpene	Colorectal cancer	Induce apoptosis	[38]
Ganoderma lucidum	Triterpene	Lung cancer	Attenuate tumor angiogenesis	[39]
Ganoderma applanatum	Polysaccharide	Breast cancer	Induce cell apoptosis through intrinsic mitochondrial apoptosis and MAPK signaling pathway.	[40]
Poria cocos	Polysaccharide	Leukemic cells	Inhibit growth and induce differentiation through increasing IFN-γ and TNF-α cytokines	[41]
Poria cocos	Polysaccharide	Liver cancer	Decrease ALB protein expression and increase VEGFA level	[42]
Poria cocos	Polysaccharide	Breast cancer	Inhibit invasion and migration	[43]
Poria cocos	Triterpene	Lung cancer	Induce cell apoptosis	[31]
Poria cocos	Triterpene	Pancreatic cancer	Decrease the expression of KRAS and matrix metalloproteinase-7	[29]
Poria cocos	Triterpene	Prostate cancer	Induction of apoptosis	[44]