Table 2.
MIND score and risk of all-cause dementia.
| Model | MAP | WHIMS | CHAP-White | CHAP-Black | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| Basic 1 | ||||||||
| MIND T1 | Ref. | Ref. | Ref. | Ref. | ||||
| MIND T2 | 0.70 (0.52, 0.94) | 0.02 | 0.88 (0.80, 0.97) | 0.008 | 0.54 (0.21, 1.43) | 0.22 | 0.82 (0.35, 1.95) | 0.66 |
| MIND T3 | 0.43 (0.30, 0.61) | <0.0001 | 0.78 (0.70, 0.86) | <0.0001 | 0.49 (0.18, 1.33) | 0.16 | 0.97 (0.32, 2.87) | 0.95 |
| Trend | 0.84 (0.77, 0.91) | <0.0001 | 0.93 (0.91, 0.96) | <0.0001 | 0.81 (0.61, 1.09) | 0.17 | 0.99 (0.73, 1.34) | 0.96 |
| Full 2 | ||||||||
| MIND T1 | Ref. | Ref. | Ref. | Ref. | ||||
| MIND T2 | 0.85 (0.62, 1.16) | 0.31 | 0.87 (0.79, 0.97) | 0.008 | 0.87 (0.30, 2.54) | 0.80 | 0.86 (0.36, 2.05) | 0.74 |
| MIND T3 | 0.63 (0.42, 0.92) | 0.02 | 0.80 (0.72, 0.89) | <0.0001 | 1.23 (0.47, 3.18) | 0.68 | 1.48 (0.51, 4.27) | 0.47 |
| Trend | 0.91 (0.83, 1.00) | 0.06 | 0.95 (0.92, 0.97) | <0.0001 | 1.00 (0.81, 1.25) | 0.97 | 1.08 (0.79, 1.48) | 0.61 |
1 Results from Cox proportional hazard (HR) or logistic (OR) regression models adjusted for age, sex (MAP, CHAP only), study center and randomization status (WHIMS only). See Supplementary Table S4 for additional covariate details. T1, T2, T3 indicate tertile 1, tertile 2 and tertile 3 MIND adherence scores, respectively. 2 Basic + education, income, global cognition score, late-life cognitive activity (MAP, CHAP only), history of diabetes, hypertension, stroke and heart disease; smoking, calorie intake, BMI, depressive symptoms and physical activity.