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. Author manuscript; available in PMC: 2022 Jul 11.
Published in final edited form as: Nature. 2022 May 11;605(7910):497–502. doi: 10.1038/s41586-022-04701-5

Extended Data Fig. 1 |. Cross design for BXD RIL construction.

Extended Data Fig. 1 |

(a) BXDs derived from F2 crosses were subject to many generations of brother-sister mating in order to generate inbred RILs. The genomes of the parents of the BXD crosses (DBA/2J and C57BL/6J) are largely derived from Mus musculus domesticus. M. m. d. is Mus musculus domesticus, M. s. is Mus spretus, M. m. m. is Mus musculus musculus, and M. m. c. is Mus musculus castaneus. (b) To generate advanced intercross lines (AILs), pseudo-random pairs of F2 animals were crossed for N generations, and then subject to many generations of brother-sister mating to generate inbred RILs.