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. 2022 Jun 21;12(11):4904–4921. doi: 10.7150/thno.74845

Figure 4.

Figure 4

Assessment of biodegradation and biosafety of Fiber-Rop/Gel-Clo composite in rats. (A) In vivo degradation of Fiber/Gel composite. Local anatomical structures of sciatic nerves and surrounding muscles, and the potential composite remnants were captured on 7, 14, and 21 days after injection. Cyan arrows indicate sciatic nerves and red arrows indicate the composite remnants. Scale bar, 1 cm. (B) Hematoxylin and eosin (H&E) staining of sciatic nerves and surrounding muscles; scale bar, 500 μm. Toluidine blue O (TBO) staining of sciatic nerves; scale bar, 100 μm. Immunohistochemical analysis of inflammatory factors (TNF-α, IL-6) in the sciatic nerve and surrounding muscles; scale bar, 500 μm. TUNEL staining of sciatic nerves; scale bar, 100 μm. 'N' and 'M' represent the sciatic nerve and muscle, respectively.