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. 2022 May 11;13(5):11767–11781. doi: 10.1080/21655979.2022.2071023

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Knockdown of Nrf2 blocked the cytoprotective effect of Klotho on H₂O₂-induced injury in ARPE-19 cells. ARPE-19 cells were transfected with Nrf2 siRNA (100 µM) using lipofectamine 2000 for 12 h, the cells were then pre-incubated with Klotho for 24 h before H₂O₂ treatment. (a, b) Western Blot was used to determine the expression levels of Nrf2, HO-1 in ARPE-19 cells. (c) The effect of siRNA Nrf2 on the proliferation of ARPE-19 cells detected by CCK-8 assay. + indicates with treatment, – indicates without treatment. Each column presented means ± SD (n = 3). Each column presented means ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.