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. 2022 Jul 9;28(12):1111–1126. doi: 10.1007/s11655-022-3576-x

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Da-cheng Hao 1, Li-jia Xu 2, Yu-wei Zheng 1, Huai-yu Lyu 1, Pei-gen Xiao 2,✉
PMCID: PMC9282152  PMID: 35809180

Abstract

Ranunculales, comprising of 7 families that are rich in medicinal species frequently utilized by traditional medicine and ethnomedicine, represents a treasure chest of biodiversity and chemodiversity. The phylogenetically related species often have similar chemical profile, which makes them often possess similar therapeutic spectrum. This has been validated by both ethnomedicinal experiences and pharmacological investigations. This paper summarizes molecular phylogeny, chemical constituents, and therapeutic applications of Ranunculales, i.e., a pharmacophylogeny study of this representative medicinal order. The phytochemistry/metabolome, ethnomedicine and bioactivity/pharmacology data are incorporated within the phylogenetic framework of Ranunculales. The most studied compounds of this order include benzylisoquinoline alkaloid, flavonoid, terpenoid, saponin and lignan, etc. Bisbenzylisoquinoline alkaloids are especially abundant in Berberidaceae and Menispermaceae. The most frequent ethnomedicinal uses are arthritis, heat-clearing and detoxification, carbuncle-abscess and sore-toxin. The most studied bioactivities are anticancer/cytotoxic, antimicrobial, and anti-inflammatory activities, etc. The pharmacophylogeny analysis, integrated with both traditional and modern medicinal uses, agrees with the molecular phylogeny based on chloroplast and nuclear DNA sequences, in which Ranunculales is divided into Ranunculaceae, Berberidaceae, Menispermaceae, Lardizabalaceae, Circaeasteraceae, Papaveraceae, and Eupteleaceae families. Chemical constituents and therapeutic efficacy of each taxonomic group are reviewed and the underlying connection between phylogeny, chemodiversity and clinical uses is revealed, which facilitate the conservation and sustainable utilization of Ranunculales pharmaceutical resources, as well as developing novel plant-based pharmacotherapy.

Electronic Supplementary Material

Supplementary material (Appendixes 1–9) is available in the online version of this article at 10.1007/s11655-022-3576-x.

Keywords: Ranunculales, chemical constituent, bioactivity, diversity, pharmacophylogeny

Electronic Supplementary Material

Appendix (951.5KB, pdf)
11655_2022_3576_MOESM2_ESM.xls (66.5KB, xls)

Supplementary material, approximately 66.5 KB.

Appendix (616.9KB, pdf)
11655_2022_3576_MOESM4_ESM.xls (70KB, xls)

Supplementary material, approximately 70.0 KB.

Author Contributions

Xiao PG, Hao DC and Xu LJ contributed to study concept and design. Hao DC undertook data analysis and interpretation and wrote the paper. Xu LJ provided financial support. Hao DC and Xu LJ contributed equally to this work. Zheng YW and Lyu HY collected data and Zheng YW drew figures.

Footnotes

Supported by the National Science and Technology Fundamental Resources Investigation Program of China (No. 2018FY100700) and CAMS Innovation Fund for Medical Sciences (No. CIFMS 2021-I2M-1-032)

Conflict of Interest

The authors declare that they have no competing interests. Author XIAO Pei-gen is a member of the Editorial Board for CJIM. The paper was handled by the other Editor and has undergone rigorous peer review process. Author XIAO Pei-gen was not involved in the journal’s review of, or decisions related to, this manuscript.

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