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. 2022 Jul 9;29(3):268–279. doi: 10.1007/s11655-022-3674-9

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation: A Systematic Review

Guilherme Vinício de Sousa Silva 1, Ana Luiza Vieira Ferreira Guimarães Lopes 1, Isis Carolina Viali 1, Lucas Zannini Medeiros Lima 1, Matheus Ribeiro Bizuti 1, Fabiana Brum Haag 2, Débora Tavares de Resende e Silva 3,✉
PMCID: PMC9282630  PMID: 35809179

Abstract

Cancers have high morbidity and mortality rates worldwide. Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis. Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis, exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells. Therefore, drugs aimed at autophagy can function as antitumor agents. Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and, consequently, consumed in diets. In this review, the systematic search strategy was used, which included the search for descriptors “flavonoids” AND “mTOR pathway” AND “cancer” AND “autophagy”, in the electronic databases of PubMed, Cochrane Library, Web of Science and Scopus, from January 2011 to January 2021. The current literature demonstrates that flavonoids have anticarcinogenic properties, including inhibition of cell proliferation, induction of apoptosis, autophagy, necrosis, cell cycle arrest, senescence, impaired cell migration, invasion, tumor angiogenesis and reduced resistance to multiple drugs in tumor cells. We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition. (Registration No. CRD42021243071 at PROSPERO)

Electronic Supplementary Material

Supplementary material (Appendices 1–2) is available in the online version of this article at 10.1007/s11655-022-3674-9.

Keywords: anti-cancer effects, apoptosis, cell proliferation, cell survival, flavonoids

Supplementary material to

11655_2022_3674_MOESM1_ESM.pdf (134.6KB, pdf)

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation: A Systematic Review

Author Contributions

Silva DTR contributed to the conception, project administration and supervision. Silva GVS, Lopes ALVFG, and Viali IC contributed to the formal analysis, investigation, and methodology. Haag FB and Bizuti MR supervised the methodology. Lima LML contributed to the writing and translation of the original draft. Bizuti MR, Silva DTR and Haag FB revised the final work.

Conflict of Interest

The authors declare that they have no conflict of interest.

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11655_2022_3674_MOESM1_ESM.pdf (134.6KB, pdf)

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation: A Systematic Review

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