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. 2022 Jun 2;65(8):1375–1389. doi: 10.1007/s00125-022-05729-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A-IDE-KO mouse pancreases exhibit increased population of large islets, increased alpha cell mass and more non-peripheral alpha cells. (a) Representative immunohistochemistry of insulin in pancreatic tissue. Scale bar, 40 μm. (b) Islet size. (c) Islet number per pancreas area. (d) Islet size distribution analysis. (e) Beta cell area. (f) Beta cell mass. (g) Intrapancreatic insulin content obtained by acid-ethanol extraction and measured by ELISA. (h) Representative immunohistochemistry of glucagon in pancreas tissue. Scale bar, 40 μm. (i) Alpha cell area per pancreas area. (j) Alpha cell mass. (k) Alpha cell size. (l) Non-peripheral alpha cell number. (m) Non-peripheral alpha cells. (n) Intrapancreatic glucagon content obtained by acid-ethanol extraction and measured by ELISA. n = 6–16 mice per group. Data are presented as means ± SEM. *p<0.05, **p<0.01 and ***p<0.001 vs control