Fig. 6.

Histology of the lungs of the infected animals at day 5 post-inoculation with SARS-CoV-2. A) The average inflammation scores of 3 mice/group from the bronchial, peribronchial, perivascular, pleural, interstitial and intra-alveolar spaces were plotted. The total inflammation scores (TIS) were also shown for each group. B) Representative micrographs of the lungs for each group. From left to right: mice injected with buffer, mice vaccinated with either 1 or 2 doses of the RBD-PapMV, mice injected with 2 doses of PapMV nano alone and non-infected negative control mice. Total inflammation scores (TIS) represent averages of triplicates. Hematoxylin-Eosin (HE) stain. Scale bar is 50 μM. ****p < 0.0001.