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The IVD-region mutations present in 9SG-NEMO abolish the ability of IKKβ(701–745) binding to induce a more compact conformation. (A) SAXS scattering curve for 9SG-NEMO with (green) and without (blue) IKKβ(701–745). (B) Guinier plot for 9SG-NEMO. Linearity at low q is not necessarily expected for a partially flexible, extended protein50,51. (C) Distance-distribution function generated by GNOM.
