Table 1.
Study participant demographics.
| Characteristic | Country | TB Patients |
Healthy controls | P-value Good vs Poor outcome 2-way comparison | P-value Combined TB groups vs HC2-way comparison | P-value Good Outcome vs Poor Outcome vs HC3 way comparison | ||
|---|---|---|---|---|---|---|---|---|
| Good Outcome | Poor Outcome | Combined TB groups | ||||||
| Total Number of Participants | S Africa | 76 | 18 | 94 | 27 | - | - | - |
| Indonesia | 61 | 20 | 81 | 0 | - | - | - | |
| All | 137 | 38 | 175 | 27 | - | - | - | |
| Age in years, median (range) | S Africa | 46 (22-68) | 42 (19-55) | 45 (19-68) | 42 (30-70) | 0.258 | 0.728 | 0.485 |
| Indonesia | 49 (25-73) | 49 (35-68) | 49 (25-73) | - | 0.96 | - | - | |
| All | 47 (22-73) | 47 (19-68) | 47 (19-73) | 42 (30-70) | 0.619 | 0.1286 | 0.2801 | |
| Sex, % male (No. male/ female) | S Africa | 58 (44/32) | 67 (12/6) | 60 (56/38) | 52 (14/13) | 0.495 | 0.474 | 0.615 |
| Indonesia | 53 (32/29) | 65(13/7) | 56 (45/36) | - | 0.258 | - | - | |
| All | 56 (76/61) | 66 (25/13) | 58(101/74) | 52 (14/13) | 0.212 | 0.567 | 0.385 | |
| Number with Diabetes / Intermediate Hyperglycaemia / Normal glycaemia (%) | S Africa | 13/49/14 | 4/11/3 | 17/60/17 | 0/0/27 | 0.8785 | <0.0001 | <0.0001 |
| Indonesia | 31/16/14 | 11/3/6 | 42/19/20 | - | 0.559 | - | - | |
| All | 44/65/28 | 15/14/9 | 59/79/37 | 0/0/27 | 0.541 | <0.0001 | <0.0001 | |
| HbA1c median (range) | S Africa | 6.0 (4.9-14.3) | 6.0 (4.8-14.1) | 6.0 (4.8 – 14.3) | 5.3 (4.8-6.4) | 0.614 | <0.0001 | <0.0001 |
| Indonesia | 8.15 (4.9-17.1) | 7.1 (5.1-14.1) | 7.8 (4.9 – 17.1) | - | 0.561 | - | - | |
| All | 6.0 (4.9-17.1) | 6.1 (4.8-14.1) | 6.0 (4.8 – 17.1) | 5.3 (4.8-6.4) | 0.989 | <0.0001 | <0.0001 | |
| BMI at TB diagnosis:, median (range) | S Africa | 18.7 (13.9-32.3) | 18.3 (13.7-31.2) | 18.7 (13.9-32.3) | 23.2 (17.4-45.2) | 0.903 | <0.0001 | 0.0001 |
| Indonesia | 19.7 (13.8-33.3) | 18.8 (16.3-27.3) | 19.6 (13.8-33.3) | - | 0.843 | - | - | |
| All | 19.1 (13.8-33.3) | 18.8 (13.7-31.2) | 19.0 (13.7-33.3) | 23.7 (17.4-45.2) | 0.835 | <0.0001 | <0.0001 | |
| TTP (days) at TB diagnosis: Median (range) (missing values) | S Africa | 6 (1-21) (18) | 6 (3-21) (3) | 6 (1-21) (21) | N/A | 0.820 | - | - |
| Smear Grade at diagnosis number: 3+/2+/1+/scanty/negative | Indonesia | 16/23/14/2/6 | 8/4/5/2/1 | 24/27/19/4/7 | N/A | 0.364 | - | - |
| Sputum conversion at Month 2: number yes/no (missing values) | S Africa | 49/19 (8) | 10/6 (2) | 59/25 (10) | N/A | 0.452 | - | - |
| Indonesia | 44/15 (2) | 10/8 (2) | 54/23 (4) | N/A | 0.123 | - | - | |
| All | 93/34 (10) | 20/14 (4) | 113/48 (14) | N/A | 0.103 | - | - | |
| Outcome classification: Cured /Recurrence/Failed/Died | S Africa | 76/0/0/0 | 0/4/10/4 | 76/4/10/4 | N/A | <0.0001 | - | - |
| Indonesia | 61/0/0/0 | 0/2/16/2 | 61/2/16/2 | N/A | <0.0001 | - | - | |
| All | 137/0/0/0 | 0/6/26/6 | 137/6/26/6 | N/A | <0.0001 | - | - | |
| RNASeq subset | S Africa | 26 | 6 | 32 | 0 | - | - | - |
| Indonesia | 23 | 8 | 31 | 0 | - | - | - | |
| All | 49 | 14 | 63 | 0 | - | - | - | |
| MLPA subset | S Africa | 76 | 18 | 94 | 27 | - | - | - |
| Indonesia | 58 | 19 | 77 | 0 | - | - | - | |
| All | 135 | 37 | 172 | 27 | - | - | - | |
Combined TB Groups is the combination of TB patients with a Good or Poor Outcome. Continuous variables were compared by Mann-Whitney U test (2 groups) or Kruskal-Wallis test (3 groups); non-continuous variables by Chi-square test.