Figure 3.

Human in the artificial intelligence loop (HAIL) annotation method. Red: neoplastic tissue. Black: region of interest. The preliminary algorithm proposes annotations, which can be approved, edited or rejected by the annotator. This process speeds up annotating and enables screening for ‘difficult’ features early in the algorithm development process. In each HAIL cycle, multiple annotations are proposed, edited, and accepted. [Colour figure can be viewed at wileyonlinelibrary.com]