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Vorinostat inhibition at HDAC1 and HDAC3. The ratio of the steady‐state velocities (mean ±SD) was plotted against the corresponding inhibitor concentrations. To determine the Ki values the resulting curves were fitted to Eq. 3. A) ratio of HDAC1/vorinostat. B) ratio of HDAC3/vorinostat. C) Calculated Ki values for vorinostat at HDAC1 and HDAC3. Experiments were performed in triplicates.
