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. Author manuscript; available in PMC: 2023 Jul 20.
Published in final edited form as: Neuron. 2022 May 17;110(14):2334–2350.e8. doi: 10.1016/j.neuron.2022.04.031

Figure 2. Cortex-wide, subtype-specific modulation of IN activity during motor learning revealed by cell type-specific wide-field calcium imaging.

Figure 2.

(A) Left, experimental setup. Right: an example field of view of wide-field calcium imaging.Scale bar, 1 mm.

(B) Activity of VIP-, SOM- and PV-INs aligned to the movement onset from example cortical regions, averaged across animals (n (VIP) = 11 mice, n (SOM) = 12 mice, n (PV) = 11 mice, mean ± SEM). S1HL: primary somatosensory cortex hindlimb area.

(C) Activity of VIP-, SOM- and PV-INs during movements in individual cortical regions at each learning stage (indicated by colors), measured by mean Δf/f between 0 and +2 s relative to the movement onset (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, mixed-effects model, corrected for multiple comparisons by false discovery rate, mean ± SEM). See also Figures S2, S3, and Movie S1.