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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Nature. 2022 May 25;606(7913):382–388. doi: 10.1038/s41586-022-04765-3

Fig. 2 |. Molecule-centric analyses suggest new mitochondrial protein functions.

Fig. 2 |

a, Relative metabolite abundance in ALDH18A1KO1 cells compared to WT cells versus statistical significance. b, Relative abundance of proline versus statistical significance across all KO lines. c, Relative lipid abundance in TAZKO1 cells compared to WT cells versus statistical significance with all CL and MLCL species highlighted. CL, cardiolipin; MLCL, Monolysocardiolipin. d, Relative abundance of CL 68:6 versus statistical significance across all KO lines. e, Relative protein abundance in SLC30A9KO cells compared to WT cells versus statistical significance with mitoribosome, OxPhos, and mtDNA-encoded proteins highlighted. f, Relative abundance of all six mtDNA-encoded proteins detected in our analyses across KO lines with ≥ 3 proteins having P < 0.05 (mean rank ordered). Data displayed as mean, n = 3–4, and two-sided Welch’s t-test for all panels.