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(A) Hypothetical interaction between azene and the receptor paralleled with the interaction of tyrosine hydroxylate of AngII. (B) Interaction of AngII with the receptor through CRS. A charge relay system of AngII demonstrates the interaction between the Tyr4 and His6 side chains and the C-terminal carboxylate of AngII and results in tyrosinate formation and receptor activation [82]. (C) Mechanism of action of Angiotensin II antagonist EXP3174 with its receptor [83].
