Table 4.
Diagnostic values of urine biomarkers in patients with ESSIC type 2 IC/BPS (from controls).
| Urine Biomarkers | AUC | Cut-off Value @: | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| 8-OHdG | 0.799 | 24.970 | 75.2% | 80.8% | 94.6% | 42.0% |
| 8-isoprostane | 0.755 | 22.245 | 68.4% | 76.9% | 92.9% | 35.7% |
| MCP-1 | 0.681 | 199.070 | 54.4% | 77.8% | 91.2% | 28.8% |
| RANTES | 0.655 | 8.770 | 41.4% | 88.9% | 94.1% | 26.1% |
| TAC | 0.649 | 845.210 | 64.9% | 65.4% | 88.9% | 30.4% |
| Eotaxin | 0.645 | 6.950 | 47.8% | 85.2% | 93.2% | 27.7% |
| CXCL10 | 0.629 | 58.425 | 26.7% | 100.0% | 100.0% | 24.1% |
| IL 8 | 0.556 | 2.165 | 84.4% | 37.0% | 85.1% | 35.7% |
| MIP-1β | 0.555 | 1.570 | 73.0% | 50.0% | 85.7% | 31.1% |
Note: 8-OHdG, 8-hydroxy-2-deoxyguanosine; TAC, total antioxidant capacity; MCP-1, macrophage chemoattractant protein-1; RANTES, regulated upon activation, normal T cell expressed and presumably secreted; CXCL10, chemokine (C-X-C motif) ligand 10; MIP-1β, macrophage inflammatory protein 1β; AUC, area under the curve of the receiver operating characteristic; PPV, positive predictive value; NPV, negative predictive value. @: units: all pg/mL, except ng/mL in 8-OHdG, and mmol/μL in TAC.