Table 5.
Pharmacokinetic parameters of GS-CBS in situ gel (IN), GS-SOL in situ gel (IN), and GS-SOL (IV).
| Formulation | Tissue/Organ | Cmax (ng/mL) | Tmax (min) | t1/2 (min) | Ke (min−1) | AUC0–t (ng/mL·min) | AUCbrain/AUCblood | Cbrain/Cblood at 30 min |
|---|---|---|---|---|---|---|---|---|
| GS-SOL (IV) | Brain | 370.8 | 30 | 301 | 0.0023 | 105,670 | 0.46 | 0.237 |
| Blood | 1964 | 10 | 77 | 0.0090 | 227,502 | |||
| GS-SOL in situ gel (IN) | Brain | 457.2 | 60 | 188 | 0.0037 | 127,598 | 1.12 | 1.228 |
| Blood | 356 | 60 | 200 | 0.0035 | 113,892 | |||
| GS-CBS in situ gel (IN) | Brain | 869.4 | 60 | 231 | 0.0030 | 316,669 | 1.26 | 1.733 |
| Blood | 752 | 120 | 193 | 0.0036 | 252,287 |