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. 2022 Jun 24;14(7):1336. doi: 10.3390/pharmaceutics14071336

Table 3.

Results of ANOVA for particle sizes (nm) and PDIs of nanoemulsions involving PC essential oil.

Particles Size (nm) PDI
Variable DF 1 Adj SS 2 Adj MS 3 F-Value p-Value DF 1 Adj SS 2 Adj MS 3 F-Value p-Value
Model 9 134,095 14,899.5 12.10 0.007 ** 9 0.044036 0.004893 11.68 0.007 **
Linear 3 56,521 18,840.4 15.31 0.006 ** 3 0.002117 0.000706 1.68 0.284 NS
S1 1 1539 1538.7 1.25 0.314 NS 1 0.001837 0.001837 4.39 0.090 NS
S2 1 15,673 15,673.2 12.73 0.016 * 1 0.000129 0.000129 0.31 0.604 NS
S3 1 39,309 39,309.4 31.93 0.002 ** 1 0.000152 0.000152 0.36 0.574 NS
Square 3 20,167 6722.2 5.46 0.049 * 3 0.017554 0.005851 13.97 0.007 **
S12 1 18,585 18,584.6 15.10 0.012 * 1 0.000154 0.000154 0.37 0.570 NS
S22 1 439 439.3 0.36 0.576 NS 1 0.003953 0.003953 9.44 0.028 *
S32 1 1046 1045.8 0.85 0.399 NS 1 0.014668 0.014668 35.02 0.002 **
2-Way Interaction 3 57,407 19,135.8 15.55 0.006 ** 3 0.024365 0.008122 19.39 0.003 **
S1S2 1 28,798 28,797.7 23.39 0.005 ** 1 0.004724 0.004724 11.28 0.020 *
S1S3 1 11,770 11,770.2 9.56 0.027 * 1 0.008882 0.008882 21.20 0.006 **
S2S3 1 16,839 16,839.4 13.68 0.014 * 1 0.010759 0.010759 25.68 0.004 **
Error 5 6155 1231.0 5 0.002094 0.000419
Lack-of-Fit 3 5149 1716.2 3.41 0.235 3 0.001901 0.000634 6.55 0.135
Pure Error 2 1006 503.1 2 0.000193 0.000097
Total 14 140,250 14 0.046130
R2 95.61% 95.46%
Adjusted R2 87.71% 87.29%

S1 = coded value of Tw80 (%), S2 = coded value of PC-EO (%), and S3 = coded value of water (%). 1 DF—degrees of freedom. 2 Adj SS: adjusted sum of square. 3 Adj MS: adjusted mean square; * p > 0.05, ** p > 0.01, and NS: nonsignificant p < 0.05.