Table 4.
Nanoparticles made of plant-derived lipids.
| Origin | Isolation and Modification | Cargoes Loaded | Administration | Therapeutic Potential | References |
|---|---|---|---|---|---|
| Grapefruit | Sucrose gradient, U/C; reassembled |
Chemotherapeutic agents (JSI-124, Paclitaxel), luciferase gene siRNA | i.v. injection | Targeted delivery of chemotherapy drug to colon tumors in xenograft model (CT26 and SW620 colon cancer in SCID mouse) | [106] |
| Sucrose gradient U/C; reassembled and folic acid coated |
miRNA | Intranasal administration | Targeted delivery to folate receptor-positive brain tumor | [107] | |
| Sucrose gradient U/C; reassembled and leukocyte plasma membrane-coated |
Doxorubicin, curcumin | i.v. injection | Targeted delivery to inflammatory tumor tissue | [108] | |
| Ginger | Reassembled | siRNA | Oral administration | Treatment of ulcerative colitis | [109] |
| Reassembled | miRNA | Oral administration | Protection against DSS-induced colitis | [37] | |
| Reassembled and folic acid-coated | Doxorubicin | i.v. injection | Treatment of colon cancer | [110] | |
| Reassembled (ultrasonication) | miRNAs | Intratracheal injection | Inhibitory effect on the expression of inflammatory cytokines and viral Nsp12 and S expression. | [55] |