Figure 9.

The substantial pathogenic action of Staphylococcus Aureus is depicted during infection of the heart and endothelial cells. The process involves three crucial stages: an increase in the inflammatory response (blue box), adhesion and internalization of the pathogen (green box), and the development of an active immune response (brown box). The external envelope of S. Aureus, consisting of the cell wall and peptidoglycans, expresses the different molecules involved in the three physopathological processes. Abbreviations: Atl, autolysin; Clfa, clumping factor A: FnBP, fibronectin binding protein; Hsc70, Heat shock cognate; Hsp60, Heat shock protein; SdrD, Serine Aspartate repeat containing protein D; TLR2, Toll-like receptor 2; TNFR1, tumor necrosis factor receptor 1.