Table 1.
Characteristics of study participants from ADNI mitochondrial genome cohort (n = 809), ROSMAP (n = 542), GSE5281 (n = 161), and AlzData (n = 540).
| ADNI | AD (n = 175) | ND (n = 634) | Diff (p) * |
| Sex (F/M) | 70 F, 105 M | 293 F, 341 M | 0.15 |
| Age, y (SD) | 73.95(7.66) | 73.04 (6.90) | 0.13 |
| ROSMAP | AD (n = 220) | ND (n = 322) | Diff (p) * |
| Sex (F/M) | 147 F, 73 M | 128 F, 194 M | <0.0001 |
| Age, y (SD) | 88(3.51) | 85.5 (5.00) | <0.0001 |
| GSE5281 | AD (n = 87) | ND (n = 74) | Diff (p) * |
| Sex (F/M) | 37 F, 50 M | 21 F, 53 M | 0.07 |
| Age, y (SD) | 79.8 (6.91) | 79.5 (8.92) | 0.8 |
| AlzData (EC) | AD (n = 39) | ND (n = 39) | Diff (p) * |
| Sex (F/M) | 18 F, 21 M | 17 F, 22 M | 1.00 |
| Age, y (SD) | 82.4 (7.38) | 78 (11.1) | 0.04 |
| AlzData (HP) | AD (n = 74) | ND (n = 66) | Diff (p) * |
| Sex (F/M) | 45 F, 29 M | 23 F, 43 M | 0.002 |
| Age, y (SD) | 83.1 (9.44) | 80.2 (9.68) | 0.07 |
| AlzData (TC) | AD (n = 52) | ND (n = 39) | Diff (p) * |
| Sex (F/M) | 14 F, 20 M * | 18 F, 21 M* | 0.81 |
| Age, y (SD) | 83.1 (9.44) | 80.2 (9.68) | 0.07 |
| AlzData (FC) | AD (n = 104) | ND (n = 128) | Diff (p) * |
| Sex (F/M) | 44 F, 46 M * | 55 F, 65 M * | 0.68 |
| Age, y (SD) | 84.7 (7.53) | 81.7 (10.60) | 0.01 |
Abbreviations: ROSMAP, the Religious Orders Study/the Rush Memory and Aging Project; ADNI, Alzheimer’s Disease Neuroimaging Initiative; AD, Alzheimer’s disease; ND, no dementia; Diff, statistical difference between AD and ND; EC, Entorhinal Cortex; HP, Hippocampus; TC, Temporal Cortex; FC, Frontal Cortex; F, female; M, male; SD, standard deviation. * Missing values exist.* p values are calculated by Fisher’s exact tests (for sex) or two-sample t-tests (for age at death, age at AD, and age).