(dMMR) |
mismatch repair deficient |
(FDA) |
Food and Drug Administration |
(HCL) |
hairy cell leukemia |
(IL-2) |
interleukin-2 |
(EU) |
European Union |
(US) |
United States |
(PD-1) |
programmed cell death protein-1 |
(CTLA-4) |
cytotoxic T -lymphocyte-associated protein-4 |
(ICPIs) |
immune checkpoint inhibitors |
(PD-L1 and PD-L2) |
programmed cell death ligands 1 and 2 |
(CHO) |
Chinese hamster ovary |
(ADCC) |
antibody-dependent cellular cytotoxicity |
(CDC) |
complement-dependent cytotoxicity |
(ADA) |
anti-drug antibodies |
(NSCLC) |
nonsmall cell lung cancer |
(PBMCs) |
human peripheral blood mononuclear cells |
(PopPk) |
population PK |
(CL) |
clearance |
(ER) |
exposure-response |
(AEs) |
adverse events |
(TMBST) |
tumor mutational burden status |
(ORR) |
overall response rate |
(APCs) |
antigen-presenting cells |
(NAbs) |
neutralizing antibodies |
(CRs) |
complete responses |
(iE) |
Induced encephalitis |
(BCMA) |
B-cell maturation antigen |
(PFS) |
progression-free survival |
(TRAEs) |
treatment-related adverse events |
(mCRC) |
colorectal cancer |