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. 2022 Jul 26;12(8):1031. doi: 10.3390/biom12081031
(dMMR) mismatch repair deficient
(FDA) Food and Drug Administration
(HCL) hairy cell leukemia
(IL-2) interleukin-2
(EU) European Union
(US) United States
(PD-1) programmed cell death protein-1
(CTLA-4) cytotoxic T -lymphocyte-associated protein-4
(ICPIs) immune checkpoint inhibitors
(PD-L1 and PD-L2) programmed cell death ligands 1 and 2
(CHO) Chinese hamster ovary
(ADCC) antibody-dependent cellular cytotoxicity
(CDC) complement-dependent cytotoxicity
(ADA) anti-drug antibodies
(NSCLC) nonsmall cell lung cancer
(PBMCs) human peripheral blood mononuclear cells
(PopPk) population PK
(CL) clearance
(ER) exposure-response
(AEs) adverse events
(TMBST) tumor mutational burden status
(ORR) overall response rate
(APCs) antigen-presenting cells
(NAbs) neutralizing antibodies
(CRs) complete responses
(iE) Induced encephalitis
(BCMA) B-cell maturation antigen
(PFS) progression-free survival
(TRAEs) treatment-related adverse events
(mCRC) colorectal cancer