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MSN GABAergic inputs onto output regions. Although GABA release from indirect pathway MSNs does not appear affected in HD, changes in GABA receptor subunits can be observed, along with reduced expression of GABA transporter GAT-3. This facilitates postsynaptic responses in GPe neurons. In the late stages of HD progression, the input of SNr/GPi neurons is significantly reduced. MSN = medium-sized spiny neuron; HD = Huntington’s disease.
