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. 2021 Aug 9;17(7):786–807. doi: 10.1080/15592294.2021.1959742

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Tip60 expression protected against alterations in the HDAC2 binding pattern along the gene body in APP larval heads. (a and b) Profile plots representing decreased (a) and increased (b) binding of HDAC2 in APP larval heads. (c and d) Profile plots representing the decreased (c) and increased (d) binding of Tip60 in APP larval heads. Profile plots also represent the significant increase in HDAC2 binding (B) and decrease in Tip60 binding (C) in APP larval heads. (Ei. and Fi.) Profile plots representing the rescue effect (reversal in APP-induced binding pattern) of Tip60 expression on HDAC2 binding. (E ii. and F ii.) The corresponding heatmaps represent the Tip60 rescue effect. Sequencing data centred + /- 0.5 kilobase from the centre region of the gene body.