Figure 6.

Tip60 and HDAC2 bind at similar genomic coordinates and co-regulate synaptic plasticity and neuronal developmental process-related genes. (a-f) The figure depicts the genome browser track view of high resolution Tip60 and HDAC2 peak analysis in three genotypes (w¹¹¹⁸, APP, and APP;Tip60) at the following genes that were identified to functionally modify neurodegeneration in the GMR-tau eye screen: Shroom (a), nwk (b), Syn (c), oc (d), nmo (e), and Appl (f) loci. The orange box highlights the blue bars below the gene features panel depicting the location of genomic region peaks bound by both Tip60 and HDAC2. These co-Tip60/HDAC2 bound peaks also contain consensus binding motifs for the following transcription factors: Adf1, brk, Bteb2, lola, luna, Mad, opa, and Sp1).