We thank Dr. Marx for his addition to our article (1) and agree with him. Hypercholesterolemia must be considered a risk factor for atherosclerosis, including in-stent neoatherosclerosis, which is a predictor of very late in-stent restenosis (2). We are not aware of a prospective study of the effects of plasmapheresis on the risk of developing in-stent restenosis, but the concept of double filtration plasmapheresis (DFPP) could reduce the concentration of adhesion molecules and thus improve endothelial function. This approach has already been presented (3).
Footnotes
Conflict of interest statement:
The authors of the contributions declare that no conflict of interest exists.
References
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