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. 2022 Aug 4;30(8):1098–1108.e6. doi: 10.1016/j.str.2022.05.007

Figure 3.

Figure 3

Detail of the structure of [IGF-I]-complexed HybZip

(A) Orthogonal views of IGF-I engagement with surrounding receptor domains.

(B) Engagement of IGF-I residue Tyr31 with a pocket at the junction of domains L1 and CR of the IGF-1R monomer.

(C) Engagement of IGF-I with domain FnIII-1 of the IR monomer.