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. Author manuscript; available in PMC: 2023 Aug 3.
Published in final edited form as: Neuron. 2022 Aug 3;110(15):2363–2385. doi: 10.1016/j.neuron.2022.06.024

Figure 5. Changes in task LFOs and neural variability with recovery.

Figure 5.

A. Rodent studies examining cortical correlates of recovery. MEAs were implanted in premotor cortex and a RTG task was used. i) Single neuron, population, and LFO neural features during a single trial of an intact animal executing a RTG movement. ii) Spike-phase coherence between neural population activity and field potential activity. iii) Change in LFO power and its relationship to behavioral recovery. (iv) Single trial neural pattern consistency (measured with a “template match” analysis) is predictive of recovery. In late, each single trial closely resembles the template; in early, there is marked variability from trial-to-trial.

B. A single stroke patient’s task-related LFO power measured with ECoG in comparison to two non-stroke subjects’ ECoG. There is reduced LFO power for movement in the stroke subject at all task timepoints. CS=central sulcus.

C. EEG based study in 32 subjects measured task-LFO strength during recovery. (i) 3 time points of measurement of LFOs (ii) increased grip-LFO power with time that correlated with recovery.