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Proposed mechanism: In response to extracellular cues (e.g., the ECM), integrin β1 locates at the tip of lamellipodia, which recruits MLCK to the leading cell edge via an unknown mechanism. The kinase then catalyzes MLC20 phosphorylation, which promotes the recruitment of c-Abl, cortactin, Pfn-1, and Abi1 to the leading edge, lamellipodial formation, and migration.
