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. 2022 Aug 4;11(15):2411. doi: 10.3390/cells11152411

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of the bitter taste receptor agonist denatonium on transepithelial ion transport of mouse tracheal epithelium. (A) Apical application of denatonium (1 mM) resulted in a decrease in the net short circuit current (I_SC). Representative current trace. (B) The denatonium-induced effect was dose-dependent with an EC₅₀ of 397 µM in wildtype mouse tracheae (n = 5 for each concentration). (C) Repeated application of denatonium (1 mM, apical) on the same trachea showed similar denatonium-modulated current changes (ΔI_SC) upon the second application (n = 5, ns: not significant). (D) The current changes (ΔI_SC) upon basolateral application of denatonium (1 mM, n = 5) were smaller than upon apical application (* p < 0.05).